ID   MA32_HUMAN     STANDARD;      PRT;   282 AA.
XX
AC   Q07021;
XX
DT   01-FEB-1995 (Rel. 31, Created)
DT   01-FEB-1995 (Rel. 31, Last sequence update)
XX
DE   COMPLEMENT COMPONENT 1, Q SUBCOMPONENT BINDING PROTEIN, MITOCHONDRIAL
DE   PRECURSOR (GLYCOPROTEIN GC1QBP) (GC1Q-R PROTEIN) (HYALURONAN-BINDING
DE   PROTEIN 1) (PRE-MRNA SPLICING FACTOR SF2, P32 SUBUNIT) (P33).
XX
KW   Mitochondrion; Transit peptide; 3D-structure.
XX
OS   Homo sapiens (Human).
OC   No information.
XX
RN   [1]
RP   SEQUENCE FROM N.A., AND SEQUENCE OF 74; 76-93 AND 208-216.
RA   Honore B., Madsen P., Rasmussen H.H., Vandekerckhove J., Celis J.E.,
RA   Leffers H.;
RT   "Cloning and expression of a cDNA covering the complete coding region
RT   of the P32 subunit of human pre-mRNA splicing factor SF2.";
RL   Gene 134:283-287(1993).
XX
RN   [2]
RP   SEQUENCE OF 5-282 FROM N.A., AND SEQUENCE OF 74-114.
RA   Krainer A.R., Mayeda A., Kozak D., Binns G.;
RT   "Functional expression of cloned human splicing factor SF2: homology
RT   to RNA-binding proteins, U1 70K, and Drosophila splicing regulators.";
RT   
RL   Cell 66:383-394(1991).
XX
RN   [3]
RP   SEQUENCE FROM N.A., AND PARTIAL SEQUENCE.
RA   Ghebrehiwet B., Lim B.L., Peerschke E.I., Willis A.C., Reid K.B.;
RT   "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface
RT   glycoprotein that binds to the globular 'heads' of C1q.";
RL   J. Exp. Med. 179:1809-1821(1994).
XX
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).
RA   Jiang J., Zhang Y., Krainer A.R., Xu R.-M.;
RT   "Crystal structure of human p32, a doughnut-shaped acidic
RT   mitochondrial matrix protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:3572-3577(1999).
XX
DR   EMBL; L04636; AAA16315.1; -. EMBL; M69039; AAA73055.1; -. EMBL;
DR   X75913; CAA53512.1; -. PIR; JT0762; JT0762. PIR; S44104; S44104. PDB;
DR   1P32; 06-APR-99. MIM; 601269; -.
XX
CC   -!- FUNCTION: NOT KNOWN. BINDS TO THE GLOBULAR "HEADS" OF C1Q THUS
CC   INHIBITING C1 ACTIVATION.
CC   -!- SUBCELLULAR LOCATION: MITOCHONDRIAL MATRIX.
CC   -!- SIMILARITY: BELONGS TO THE MAM33 FAMILY.
CC   -!- CAUTION: WAS ORIGINALLY (REF.1 AND REF.2) THOUGHT TO BE A PRE-MRNA
CC   SPLICING FACTOR THAT PLAYS A ROLE IN PREVENTING EXON SKIPPING,
CC   ENSURING THE ACCURACY OF SPLICING AND REGULATING ALTERNATIVE
CC   SPLICING.
CC   ----------------------------------------------------------------------
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XX
SQ   Sequence 282 BP; 17 A; 7 C; 20 G; 16 T; 222 other;
     MLPLLRCVPR VLGSSVAGLR AAAPASPFRQ LLQPAPRLCT RPFGLLSVRA GSERRPGLLR
     PRGPCACGCG CGSLHTDGDK AFVDFLSDEI KEERKIQKHK TLPKMSGGWE LELNGTEAKL
     VRKVAGEKIT VTFNINNSIP PTFDGEEEPS QGQKVEEQEP ELTSTPNFVV EVIKNDDGKK
     ALVLDCHYPE DEVGQEDEAE SDIFSIREVS FQSTGESEWK DTNYTLNTDS LDWALYDHLM
     DFLADRGVDN TFADELVELS TALEHQEYIT FLEDLKSFVK SQ
//
